Model : liver_glucose_8_const_glyglc

Creator
Matthias, Koenig, Humboldt-University Berlin, Institute for Theoretical Biology, koenigmx@hu-berlin.de
Created: 2020-01-02 18:16
Modified: 2020-01-02 18:16

id liver_glucose_8_const_glyglc meta_liver_glucose_8
nameliver_glucose_8
timemin
substancemmole
extentmmole
volumelitre
aream2
lengthm
L3V1 fbc-V2 comp-V1

Koenig Human Glucose Metabolism

Description

This is a metabolism model of Human glucose metabolism in SBML format.

This model is based on the model described in the article:

König M., Bulik S., Holzhütter HG.
PLoS Comput Biol. 2012;8(6)
The content of this model has been carefully created in a manual research effort.
This file has been created by Matthias Koenig.

Terms of use

Copyright © 2020 Matthias Koenig.

Redistribution and use of any part of this model, with or without modification, are permitted provided that the following conditions are met:

  1. Redistributions of this SBML file must retain the above copyright notice, this list of conditions and the following disclaimer.
  2. Redistributions in a different form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
This model is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.


Ports [14] name referenced element port ref id ref unit ref metaid ref sbo cvterm
s_port s_port s_port UnitDefinition: s s
min_port min_port min_port UnitDefinition: min min
kg_port kg_port kg_port UnitDefinition: kg kg
m_port m_port m_port UnitDefinition: m m
m2_port m2_port m2_port UnitDefinition: m2 m2
m3_port m3_port m3_port UnitDefinition: m3 m3
mmole_port mmole_port mmole_port UnitDefinition: mmole mmole
mM_port mM_port mM_port UnitDefinition: mM mM
per_s_port per_s_port per_s_port UnitDefinition: per_s per_s
per_min_port per_min_port per_min_port UnitDefinition: per_min per_min
ext_port ext_port ext_port Compartment: ext ext
cyto_port cyto_port cyto_port Compartment: cyto cyto
glc_ext_port glc_ext_port glc_ext_port Species: glc_ext glc_ext
lac_ext_port lac_ext_port lac_ext_port Species: lac_ext lac_ext

FunctionDefinitions [2] name math sbo cvterm
max minimum of arguments x y x x y y
min maximum of arguments x y x x y y

UnitDefinitions [19] name units sbo cvterm
s s
min 60 s
kg kg
m m
m2 m 2
m3 m 3
mmole 10 3 mole
mM 10 3 mole litre
per_s 1 s
per_min 1 60 s
s_per_min s 60 s
per_mM m 3 mole
mM2 mole 2 m 6
pmol 10 12 mole
pM 10 12 mole litre
mmole_per_min 10 3 mole 60 s
mumole_per_mmole 10 6 mole 10 3 mole
mumole_per_mmole_kg 10 6 mole kg 10 3 mole
mumol_per_min_kg 10 6 mole kg 60 s

Compartments [5] name size constant spatial dimensions units derived units sbo cvterm
ext meta_ext blood 1.0 3 litre litre
cyto meta_cyto cytosol V_cyto 3 litre litre
mito meta_mito mitochondrion V_mito 3 litre litre
pm meta_pm plasma membrane 1.0 2 m2 m 2
mm meta_mm mitochondrial membrane 1.0 2 m2 m 2

Species [49] name compartment hasOnlySubstanceUnits boundaryCondition constant initialAmount initialConcentration conversionFactor units substanceUnits derivedUnits sbo cvterm
atp meta_atp ATP
C10H12N5O13P3 (-4)
cyto 2.8 mmole mmole 10 3 mole litre
adp meta_adp ADP
C10H12N5O10P2 (-3)
cyto 0.8 mmole mmole 10 3 mole litre
amp meta_amp AMP
C10H12N5O7P (-2)
cyto 0.16 mmole mmole 10 3 mole litre
utp meta_utp UTP
C9H11N2O15P3 (-4)
cyto 0.27 mmole mmole 10 3 mole litre
udp meta_udp UDP
C9H11N2O12P2 (-3)
cyto 0.09 mmole mmole 10 3 mole litre
gtp meta_gtp GTP
C10H12N5O14P3 (-4)
cyto 0.29 mmole mmole 10 3 mole litre
gdp meta_gdp GDP
C10H12N5O11P2 (-3)
cyto 0.1 mmole mmole 10 3 mole litre
nad meta_nad NAD+
C21H26N7O14P2 (-1)
cyto 1.22 mmole mmole 10 3 mole litre
nadh meta_nadh NADH
C21H27N7O14P2 (-2)
cyto 0.00056 mmole mmole 10 3 mole litre
phos meta_phos phosphate
HO4P (-2)
cyto 5.0 mmole mmole 10 3 mole litre
pp meta_pp pyrophosphate
HO7P2 (-3)
cyto 0.008 mmole mmole 10 3 mole litre
co2 meta_co2 CO2
CO2
cyto 5.0 mmole mmole 10 3 mole litre
h2o meta_h2o H2O
H2O
cyto 0.0 mmole mmole 10 3 mole litre
h meta_h H+
H (1)
cyto 0.0 mmole mmole 10 3 mole litre
glc1p meta_glc1p glucose-1 phosphate
C6H11O9P (-2)
cyto 0.012 mmole mmole 10 3 mole litre
udpglc meta_udpglc UDP-glucose
C15H22N2O17P2 (-2)
cyto 0.38 mmole mmole 10 3 mole litre
glyglc meta_glyglc glycogen
C6H12O6
cyto 250.0 mmole mmole 10 3 mole litre
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
C00182; CHEBI:28087
glc meta_glc glucose
C6H12O6
cyto 5.0 mmole mmole 10 3 mole litre
glc6p meta_glc6p glucose-6 phosphate
C6H11O9P (-2)
cyto 0.12 mmole mmole 10 3 mole litre
fru6p meta_fru6p fructose-6 phosphate
C6H11O9P (-2)
cyto 0.05 mmole mmole 10 3 mole litre
fru16bp meta_fru16bp fructose-16 bisphosphate
C6H10O12P2 (-4)
cyto 0.02 mmole mmole 10 3 mole litre
fru26bp meta_fru26bp fructose-26 bisphosphate
C6H10O12P2 (-4)
cyto 0.004 mmole mmole 10 3 mole litre
grap meta_grap glyceraldehyde 3-phosphate
C3H5O6P (-2)
cyto 0.1 mmole mmole 10 3 mole litre
dhap meta_dhap dihydroxyacetone phosphate
C3H5O6P (-2)
cyto 0.03 mmole mmole 10 3 mole litre
bpg13 meta_bpg13 13-bisphospho-glycerate
C3H4O10P2 (-4)
cyto 0.3 mmole mmole 10 3 mole litre
pg3 meta_pg3 3-phosphoglycerate
C3H4O7P (-3)
cyto 0.27 mmole mmole 10 3 mole litre
pg2 meta_pg2 2-phosphoglycerate
C3H4O7P (-3)
cyto 0.03 mmole mmole 10 3 mole litre
pep meta_pep phosphoenolpyruvate
C3H2O6P (-3)
cyto 0.15 mmole mmole 10 3 mole litre
pyr meta_pyr pyruvate
C3H3O3 (-1)
cyto 0.1 mmole mmole 10 3 mole litre
oaa meta_oaa oxaloacetate
C4H2O5 (-2)
cyto 0.01 mmole mmole 10 3 mole litre
lac meta_lac lactate
C3H5O3 (-1)
cyto 0.5 mmole mmole 10 3 mole litre
glc_ext meta_glc_ext glucose
C6H12O6
ext 3.0 mmole mmole 10 3 mole litre
lac_ext meta_lac_ext lactate
C3H5O3 (-1)
ext 1.2 mmole mmole 10 3 mole litre
co2_mito meta_co2_mito CO2
CO2
mito 5.0 mmole mmole 10 3 mole litre
phos_mito meta_phos_mito phosphate
HO4P (-2)
mito 5.0 mmole mmole 10 3 mole litre
oaa_mito meta_oaa_mito oxaloacetate
C4H2O5 (-2)
mito 0.01 mmole mmole 10 3 mole litre
pep_mito meta_pep_mito phosphoenolpyruvate
C3H2O6P (-3)
mito 0.15 mmole mmole 10 3 mole litre
acoa_mito meta_acoa_mito acetyl-coenzyme A
C23H34N7O17P3S (-4)
mito 0.04 mmole mmole 10 3 mole litre
pyr_mito meta_pyr_mito pyruvate
C3H3O3 (-1)
mito 0.1 mmole mmole 10 3 mole litre
cit_mito meta_cit_mito citrate
C6H5O7 (-3)
mito 0.32 mmole mmole 10 3 mole litre
atp_mito meta_atp_mito ATP
C10H12N5O13P3 (-4)
mito 2.8 mmole mmole 10 3 mole litre
adp_mito meta_adp_mito ADP
C10H12N5O10P2 (-3)
mito 0.8 mmole mmole 10 3 mole litre
gtp_mito meta_gtp_mito GTP
C10H12N5O14P3 (-4)
mito 0.29 mmole mmole 10 3 mole litre
gdp_mito meta_gdp_mito GDP
C10H12N5O11P2 (-3)
mito 0.1 mmole mmole 10 3 mole litre
coa_mito meta_coa_mito coenzyme A
C21H32N7O16P3S (-4)
mito 0.055 mmole mmole 10 3 mole litre
nadh_mito meta_nadh_mito NADH
C21H27N7O14P2 (-2)
mito 0.24 mmole mmole 10 3 mole litre
nad_mito meta_nad_mito NAD+
C21H26N7O14P2 (-1)
mito 0.98 mmole mmole 10 3 mole litre
h2o_mito meta_h2o_mito H20
H2O
mito 0.0 mmole mmole 10 3 mole litre
h_mito meta_h_mito H+
H (1)
mito 0.0 mmole mmole 10 3 mole litre

Parameters [257] name constant value unit derived unit sbo cvterm
scale scaling factor for rates 1.0 dimensionless None
V_cyto cytosolic volume 1.0 litre litre
f_mito mitochondrial volume factor 0.2 dimensionless None
Vliver liver volume 1.5 litre litre
fliver parenchymal fraction liver 0.583333333333334 dimensionless None
bodyweight bodyweight 70.0 kg kg
sec_per_min time conversion 60.0 s_per_min s 60 s
mumole_per_mmole amount conversion 1000.0 mumole_per_mmole 10 6 mole 10 3 mole
x_ins1 818.9 pM 10 12 mole litre
x_ins2 0.0 pM 10 12 mole litre
x_ins3 8.6 mM 10 3 mole litre
x_ins4 4.2 dimensionless None
x_glu1 190.0 pM 10 12 mole litre
x_glu2 37.9 pM 10 12 mole litre
x_glu3 3.01 mM 10 3 mole litre
x_glu4 6.4 dimensionless None
x_epi1 6090.0 pM 10 12 mole litre
x_epi2 100.0 pM 10 12 mole litre
x_epi3 3.1 mM 10 3 mole litre
x_epi4 8.4 dimensionless None
K_val 0.1 dimensionless None
epi_f 0.8 dimensionless None
V_mito mitochondrial volume f_mito V_cyto m3 m 3
flux_conversion mumole_per_mmole bodyweight mumole_per_mmole_kg 10 6 mole kg 10 3 mole
f_gly scaling factor glycolysis scale dimensionless None
f_glyglc scaling factor glycogen metabolism scale dimensionless None
ins meta_ins insulin x_ins2 x_ins1 x_ins2 glc_ext x_ins4 glc_ext x_ins4 x_ins3 x_ins4 pM 10 12 mole litre
ins_norm insulin normalized max 0 ins x_ins2 pM 10 12 mole litre
glu meta_glu glucagon x_glu2 x_glu1 x_glu2 1 glc_ext x_glu4 glc_ext x_glu4 x_glu3 x_glu4 pM 10 12 mole litre
glu_norm glucagon normalized max 0 glu x_glu2 pM 10 12 mole litre
epi meta_epi epinephrine x_epi2 x_epi1 x_epi2 1 glc_ext x_epi4 glc_ext x_epi4 x_epi3 x_epi4 pM 10 12 mole litre
epi_norm epinephrine normalized max 0 epi x_epi2 pM 10 12 mole litre
K_ins x_ins1 x_ins2 K_val pM 10 12 mole litre
K_glu x_glu1 x_glu2 K_val pM 10 12 mole litre
K_epi x_epi1 x_epi2 K_val pM 10 12 mole litre
gamma phosphorylation state 0.5 1 ins_norm ins_norm K_ins max glu_norm glu_norm K_glu epi_f epi_norm epi_norm K_epi dimensionless None
nadh_tot NADH balance nadh nad mM 10 3 mole litre
atp_tot ATP balance atp adp amp mM 10 3 mole litre
utp_tot UTP balance utp udp udpglc mM 10 3 mole litre
gtp_tot GTP balance gtp gdp mM 10 3 mole litre
nadh_mito_tot NADH mito balance nadh_mito nad_mito mM 10 3 mole litre
atp_mito_tot ATP mito balance atp_mito adp_mito mM 10 3 mole litre
gtp_mito_tot GTP mito balance gtp_mito gdp_mito mM 10 3 mole litre
HGP hepatic glucose production/utilization GLUT2 flux_conversion mumol_per_min_kg 10 6 mole kg 60 s
GNG gluconeogenesis/glycolysis GPI flux_conversion mumol_per_min_kg 10 6 mole kg 60 s
GLY glycogenolysis/glycogen synthesis G16PI flux_conversion mumol_per_min_kg 10 6 mole kg 60 s
GLUT2_keq meta_GLUT2_keq 1.0 dimensionless None
GLUT2_k_glc meta_GLUT2_k_glc 42.0 mM 10 3 mole litre
GLUT2_Vmax meta_GLUT2_Vmax 420.0 mmole_per_min 10 3 mole 60 s
GK_n_gkrp 2.0 dimensionless None
GK_k_glc1 meta_GK_k_glc1 15.0 mM 10 3 mole litre
GK_k_fru6p meta_GK_k_fru6p 0.01 mM 10 3 mole litre
GK_b 0.7 dimensionless None
GK_n 1.6 dimensionless None
GK_k_glc meta_GK_k_glc 7.5 mM 10 3 mole litre
GK_k_atp meta_GK_k_atp 0.26 mM 10 3 mole litre
GK_Vmax meta_GK_Vmax 25.2 mmole_per_min 10 3 mole 60 s
GK_gc_free glc GK_n_gkrp glc GK_n_gkrp GK_k_glc1 GK_n_gkrp 1 GK_b fru6p fru6p GK_k_fru6p dimensionless None
G6PASE_k_glc6p meta_G6PASE_k_glc6p 2.0 mM 10 3 mole litre
G6PASE_Vmax meta_G6PASE_Vmax 18.9 mmole_per_min 10 3 mole 60 s
GPI_keq meta_GPI_keq 0.517060817492925 dimensionless None
GPI_k_glc6p meta_GPI_k_glc6p 0.182 mM 10 3 mole litre
GPI_k_fru6p meta_GPI_k_fru6p 0.071 mM 10 3 mole litre
GPI_Vmax meta_GPI_Vmax 420.0 mmole_per_min 10 3 mole 60 s
G16PI_keq meta_G16PI_keq 15.7175540821514 dimensionless None
G16PI_k_glc6p meta_G16PI_k_glc6p 0.67 mM 10 3 mole litre
G16PI_k_glc1p meta_G16PI_k_glc1p 0.045 mM 10 3 mole litre
G16PI_Vmax meta_G16PI_Vmax 100.0 mmole_per_min 10 3 mole 60 s
UPGASE_keq meta_UPGASE_keq 0.312237619153088 dimensionless None
UPGASE_k_utp meta_UPGASE_k_utp 0.563 mM 10 3 mole litre
UPGASE_k_glc1p meta_UPGASE_k_glc1p 0.172 mM 10 3 mole litre
UPGASE_k_udpglc meta_UPGASE_k_udpglc 0.049 mM 10 3 mole litre
UPGASE_k_pp meta_UPGASE_k_pp 0.166 mM 10 3 mole litre
UPGASE_Vmax meta_UPGASE_Vmax 80.0 mmole_per_min 10 3 mole 60 s
PPASE_k_pp meta_PPASE_k_pp 0.005 mM 10 3 mole litre
PPASE_Vmax meta_PPASE_Vmax 2.4 mmole_per_min 10 3 mole 60 s
GS_C 500.0 mM 10 3 mole litre
GS_k1_max 0.2 dimensionless None
GSn_k1 0.224 mM2 mole 2 m 6
GSp_k1 3.003 mM2 mole 2 m 6
GSn_k2 0.1504 mM 10 3 mole litre
GSp_k2 0.09029 mM 10 3 mole litre
GS_Vmax meta_GS_Vmax 13.2 mmole_per_min 10 3 mole 60 s
GS_fs 1 GS_k1_max GS_C glyglc GS_C glyglc GS_k1_max GS_C dimensionless None
GSn_k_udpglc meta_GSn_k_udpglc GSn_k1 glc6p GSn_k2 mM 10 3 mole litre
GSp_k_udpglc meta_GSp_k_udpglc GSp_k1 glc6p GSp_k2 mM 10 3 mole litre
GSn f_glyglc GS_Vmax GS_fs udpglc GSn_k_udpglc udpglc mmole_per_min 10 3 mole 60 s
GSp f_glyglc GS_Vmax GS_fs udpglc GSp_k_udpglc udpglc mmole_per_min 10 3 mole 60 s
GP_keq meta_GP_keq 0.211826505793075 per_mM m 3 mole
GPn_k_glyglc meta_GPn_k_glyglc 4.8 mM 10 3 mole litre
GPp_k_glyglc meta_GPp_k_glyglc 2.7 mM 10 3 mole litre
GPn_k_glc1p meta_GPn_k_glc1p 120.0 mM 10 3 mole litre
GPp_k_glc1p meta_GPp_k_glc1p 2.0 mM 10 3 mole litre
GPn_k_phos meta_GPn_k_phos 300.0 mM 10 3 mole litre
GPp_k_phos meta_GPp_k_phos 5.0 mM 10 3 mole litre
GPp_ki_glc meta_GPp_ki_glc 5.0 mM 10 3 mole litre
GPn_ka_amp 1.0 mM 10 3 mole litre
GPn_base_amp 0.03 dimensionless None
GPn_max_amp 0.3 dimensionless None
GP_Vmax meta_GP_Vmax 6.8 mmole_per_min 10 3 mole 60 s
GP_fmax 1 GS_k1_max glyglc glyglc GS_k1_max GS_C dimensionless None
GPn_Vmax meta_GPn_Vmax f_glyglc GP_Vmax GP_fmax GPn_base_amp GPn_max_amp GPn_base_amp amp amp GPn_ka_amp mmole_per_min 10 3 mole 60 s
GPn GPn_Vmax GPn_k_glyglc GPn_k_phos glyglc phos glc1p GP_keq 1 glyglc GPn_k_glyglc 1 phos GPn_k_phos 1 glc1p GPn_k_glc1p 1 mmole_per_min 10 3 mole 60 s
GPp_Vmax meta_GPp_Vmax f_glyglc GP_Vmax GP_fmax 10 2 GPp_ki_glc glc mmole_per_min 10 3 mole 60 s
GPp GPp_Vmax GPp_k_glyglc GPp_k_phos glyglc phos glc1p GP_keq 1 glyglc GPp_k_glyglc 1 phos GPp_k_phos 1 glc1p GPp_k_glc1p 1 mmole_per_min 10 3 mole 60 s
NDKGTP_keq meta_NDKGTP_keq 1.0 dimensionless None
NDKGTP_k_atp meta_NDKGTP_k_atp 1.33 mM 10 3 mole litre
NDKGTP_k_adp meta_NDKGTP_k_adp 0.042 mM 10 3 mole litre
NDKGTP_k_gtp meta_NDKGTP_k_gtp 0.15 mM 10 3 mole litre
NDKGTP_k_gdp meta_NDKGTP_k_gdp 0.031 mM 10 3 mole litre
NDKGTP_Vmax meta_NDKGTP_Vmax 0.0 mmole_per_min 10 3 mole 60 s
NDKUTP_keq meta_NDKUTP_keq 1.0 dimensionless None
NDKUTP_k_atp meta_NDKUTP_k_atp 1.33 mM 10 3 mole litre
NDKUTP_k_adp meta_NDKUTP_k_adp 0.042 mM 10 3 mole litre
NDKUTP_k_utp meta_NDKUTP_k_utp 16.0 mM 10 3 mole litre
NDKUTP_k_udp meta_NDKUTP_k_udp 0.19 mM 10 3 mole litre
NDKUTP_Vmax meta_NDKUTP_Vmax 2940.0 mmole_per_min 10 3 mole 60 s
AK_keq meta_AK_keq 0.247390074904985 dimensionless None
AK_k_atp meta_AK_k_atp 0.09 mM 10 3 mole litre
AK_k_amp meta_AK_k_amp 0.08 mM 10 3 mole litre
AK_k_adp meta_AK_k_adp 0.11 mM 10 3 mole litre
AK_Vmax meta_AK_Vmax 0.0 mmole_per_min 10 3 mole 60 s
PFK2n_n 1.3 dimensionless None
PFK2p_n 2.1 dimensionless None
PFK2n_k_fru6p meta_PFK2n_k_fru6p 0.016 mM 10 3 mole litre
PFK2p_k_fru6p meta_PFK2p_k_fru6p 0.05 mM 10 3 mole litre
PFK2n_k_atp meta_PFK2n_k_atp 0.28 mM 10 3 mole litre
PFK2p_k_atp meta_PFK2p_k_atp 0.65 mM 10 3 mole litre
PFK2_Vmax meta_PFK2_Vmax 0.0042 mmole_per_min 10 3 mole 60 s
PFK2n f_gly PFK2_Vmax fru6p PFK2n_n fru6p PFK2n_n PFK2n_k_fru6p PFK2n_n atp atp PFK2n_k_atp mmole_per_min 10 3 mole 60 s
PFK2p f_gly PFK2_Vmax fru6p PFK2p_n fru6p PFK2p_n PFK2p_k_fru6p PFK2p_n atp atp PFK2p_k_atp mmole_per_min 10 3 mole 60 s
FBP2n_k_fru26bp meta_FBP2n_k_fru26bp 0.01 mM 10 3 mole litre
FBP2p_k_fru26bp meta_FBP2p_k_fru26bp 0.0005 mM 10 3 mole litre
FBP2n_ki_fru6p meta_FBP2n_ki_fru6p 0.0035 mM 10 3 mole litre
FBP2p_ki_fru6p meta_FBP2p_ki_fru6p 0.01 mM 10 3 mole litre
FBP2_Vmax meta_FBP2_Vmax 0.126 mmole_per_min 10 3 mole 60 s
FBP2n f_gly FBP2_Vmax 1 fru6p FBP2n_ki_fru6p fru26bp FBP2n_k_fru26bp fru26bp mmole_per_min 10 3 mole 60 s
FBP2p f_gly FBP2_Vmax 1 fru6p FBP2p_ki_fru6p fru26bp FBP2p_k_fru26bp fru26bp mmole_per_min 10 3 mole 60 s
PFK1_k_atp meta_PFK1_k_atp 0.111 mM 10 3 mole litre
PFK1_k_fru6p meta_PFK1_k_fru6p 0.077 mM 10 3 mole litre
PFK1_ki_fru6p meta_PFK1_ki_fru6p 0.012 mM 10 3 mole litre
PFK1_ka_fru26bp 0.001 mM 10 3 mole litre
PFK1_Vmax meta_PFK1_Vmax 7.182 mmole_per_min 10 3 mole 60 s
FBP1_ki_fru26bp meta_FBP1_ki_fru26bp 0.001 mM 10 3 mole litre
FBP1_k_fru16bp meta_FBP1_k_fru16bp 0.0013 mM 10 3 mole litre
FBP1_Vmax meta_FBP1_Vmax 4.326 mmole_per_min 10 3 mole 60 s
ALD_keq meta_ALD_keq 9.76298897362969e-05 mM 10 3 mole litre
ALD_k_fru16bp meta_ALD_k_fru16bp 0.0071 mM 10 3 mole litre
ALD_k_dhap meta_ALD_k_dhap 0.0364 mM 10 3 mole litre
ALD_k_grap meta_ALD_k_grap 0.0071 mM 10 3 mole litre
ALD_ki1_grap 0.0572 mM 10 3 mole litre
ALD_ki2_grap 0.176 mM 10 3 mole litre
ALD_Vmax meta_ALD_Vmax 420.0 mmole_per_min 10 3 mole 60 s
TPI_keq meta_TPI_keq 0.054476985386756 dimensionless None
TPI_k_dhap meta_TPI_k_dhap 0.59 mM 10 3 mole litre
TPI_k_grap meta_TPI_k_grap 0.42 mM 10 3 mole litre
TPI_Vmax meta_TPI_Vmax 420.0 mmole_per_min 10 3 mole 60 s
GAPDH_keq meta_GAPDH_keq 0.086779866194594 per_mM m 3 mole
GAPDH_k_nad meta_GAPDH_k_nad 0.05 mM 10 3 mole litre
GAPDH_k_grap meta_GAPDH_k_grap 0.005 mM 10 3 mole litre
GAPDH_k_phos meta_GAPDH_k_phos 3.9 mM 10 3 mole litre
GAPDH_k_nadh meta_GAPDH_k_nadh 0.0083 mM 10 3 mole litre
GAPDH_k_bpg13 meta_GAPDH_k_bpg13 0.0035 mM 10 3 mole litre
GAPDH_Vmax meta_GAPDH_Vmax 420.0 mmole_per_min 10 3 mole 60 s
PGK_keq meta_PGK_keq 6.95864405248854 dimensionless None
PGK_k_adp meta_PGK_k_adp 0.35 mM 10 3 mole litre
PGK_k_atp meta_PGK_k_atp 0.48 mM 10 3 mole litre
PGK_k_bpg13 meta_PGK_k_bpg13 0.002 mM 10 3 mole litre
PGK_k_pg3 meta_PGK_k_pg3 1.2 mM 10 3 mole litre
PGK_Vmax meta_PGK_Vmax 420.0 mmole_per_min 10 3 mole 60 s
PGM_keq meta_PGM_keq 0.181375378837397 dimensionless None
PGM_k_pg3 meta_PGM_k_pg3 5.0 mM 10 3 mole litre
PGM_k_pg2 meta_PGM_k_pg2 1.0 mM 10 3 mole litre
PGM_Vmax meta_PGM_Vmax 420.0 mmole_per_min 10 3 mole 60 s
EN_keq meta_EN_keq 0.054476985386756 dimensionless None
EN_k_pep meta_EN_k_pep 1.0 mM 10 3 mole litre
EN_k_pg2 meta_EN_k_pg2 1.0 mM 10 3 mole litre
EN_Vmax meta_EN_Vmax 35.994 mmole_per_min 10 3 mole 60 s
PKn_n 3.5 dimensionless None
PKp_n 3.5 dimensionless None
PKn_n_fbp 1.8 dimensionless None
PKp_n_fbp 1.8 dimensionless None
PKn_alpha 1.0 dimensionless None
PKp_alpha 1.1 dimensionless None
PKn_k_fbp meta_PKn_k_fbp 0.00016 mM 10 3 mole litre
PKp_k_fbp meta_PKp_k_fbp 0.00035 mM 10 3 mole litre
PKn_k_pep meta_PKn_k_pep 0.58 mM 10 3 mole litre
PKp_k_pep meta_PKp_k_pep 1.1 mM 10 3 mole litre
PKn_ba 0.08 dimensionless None
PKp_ba 0.04 dimensionless None
PK_ae 1.0 dimensionless None
PKn_k_pep_end meta_PKn_k_pep_end 0.08 mM 10 3 mole litre
PK_k_adp meta_PK_k_adp 2.3 mM 10 3 mole litre
PK_Vmax meta_PK_Vmax 46.2 mmole_per_min 10 3 mole 60 s
PKn_f fru16bp PKn_n_fbp PKn_k_fbp PKn_n_fbp fru16bp PKn_n_fbp dimensionless None
PKp_f fru16bp PKp_n_fbp PKp_k_fbp PKp_n_fbp fru16bp PKp_n_fbp dimensionless None
PKn_alpha_inp 1 PKn_f PKn_alpha PK_ae PK_ae dimensionless None
PKp_alpha_inp 1 PKp_f PKp_alpha PK_ae PK_ae dimensionless None
PKn_pep_inp 1 PKn_f PKn_k_pep PKn_k_pep_end PKn_k_pep_end mM 10 3 mole litre
PKp_pep_inp 1 PKp_f PKp_k_pep PKn_k_pep_end PKn_k_pep_end mM 10 3 mole litre
PKn f_gly PK_Vmax PKn_alpha_inp pep PKn_n PKn_pep_inp PKn_n pep PKn_n adp adp PK_k_adp PKn_ba 1 PKn_ba PKn_f mmole_per_min 10 3 mole 60 s
PKp f_gly PK_Vmax PKp_alpha_inp pep PKp_n PKp_pep_inp PKp_n pep PKp_n adp adp PK_k_adp PKp_ba 1 PKp_ba PKp_f mmole_per_min 10 3 mole 60 s
PEPCK_keq meta_PEPCK_keq 336.956521586429 mM 10 3 mole litre
PEPCK_k_pep meta_PEPCK_k_pep 0.237 mM 10 3 mole litre
PEPCK_k_gdp meta_PEPCK_k_gdp 0.0921 mM 10 3 mole litre
PEPCK_k_co2 meta_PEPCK_k_co2 25.5 mM 10 3 mole litre
PEPCK_k_oaa meta_PEPCK_k_oaa 0.0055 mM 10 3 mole litre
PEPCK_k_gtp meta_PEPCK_k_gtp 0.0222 mM 10 3 mole litre
PEPCK_Vmax meta_PEPCK_Vmax 0.0 mmole_per_min 10 3 mole 60 s
PEPCKM_Vmax meta_PEPCKM_Vmax 546.0 mmole_per_min 10 3 mole 60 s
PC_k_atp meta_PC_k_atp 0.22 mM 10 3 mole litre
PC_k_pyr meta_PC_k_pyr 0.22 mM 10 3 mole litre
PC_k_co2 meta_PC_k_co2 3.2 mM 10 3 mole litre
PC_k_acoa meta_PC_k_acoa 0.015 mM 10 3 mole litre
PC_n 2.5 dimensionless None
PC_Vmax meta_PC_Vmax 168.0 mmole_per_min 10 3 mole 60 s
LDH_keq meta_LDH_keq 0.000278321076004752 dimensionless None
LDH_k_pyr meta_LDH_k_pyr 0.495 mM 10 3 mole litre
LDH_k_lac meta_LDH_k_lac 31.98 mM 10 3 mole litre
LDH_k_nad meta_LDH_k_nad 0.984 mM 10 3 mole litre
LDH_k_nadh meta_LDH_k_nadh 0.027 mM 10 3 mole litre
LDH_Vmax meta_LDH_Vmax 12.6 mmole_per_min 10 3 mole 60 s
LACT_keq meta_LACT_keq 1.0 dimensionless None
LACT_k_lac meta_LACT_k_lac 0.8 mM 10 3 mole litre
LACT_Vmax meta_LACT_Vmax 5.418 mmole_per_min 10 3 mole 60 s
PYRTM_keq meta_PYRTM_keq 1.0 dimensionless None
PYRTM_k_pyr meta_PYRTM_k_pyr 0.1 mM 10 3 mole litre
PYRTM_Vmax meta_PYRTM_Vmax 42.0 mmole_per_min 10 3 mole 60 s
PEPTM_keq meta_PEPTM_keq 1.0 dimensionless None
PEPTM_k_pep meta_PEPTM_k_pep 0.1 mM 10 3 mole litre
PEPTM_Vmax meta_PEPTM_Vmax 33.6 mmole_per_min 10 3 mole 60 s
PDH_k_pyr meta_PDH_k_pyr 0.025 mM 10 3 mole litre
PDH_k_coa meta_PDH_k_coa 0.013 mM 10 3 mole litre
PDH_k_nad meta_PDH_k_nad 0.05 mM 10 3 mole litre
PDH_ki_acoa meta_PDH_ki_acoa 0.035 mM 10 3 mole litre
PDH_ki_nadh meta_PDH_ki_nadh 0.036 mM 10 3 mole litre
PDHn_alpha 5.0 dimensionless None
PDHp_alpha 1.0 dimensionless None
PDH_Vmax meta_PDH_Vmax 13.44 mmole_per_min 10 3 mole 60 s
PDH_base f_gly PDH_Vmax pyr_mito pyr_mito PDH_k_pyr nad_mito nad_mito PDH_k_nad 1 nadh_mito PDH_ki_nadh coa_mito coa_mito PDH_k_coa 1 acoa_mito PDH_ki_acoa mmole_per_min 10 3 mole 60 s
PDHn PDH_base PDHn_alpha mmole_per_min 10 3 mole 60 s
PDHp PDH_base PDHp_alpha mmole_per_min 10 3 mole 60 s
CS_keq meta_CS_keq 266599.030842759 dimensionless None
CS_k_oaa meta_CS_k_oaa 0.002 mM 10 3 mole litre
CS_k_acoa meta_CS_k_acoa 0.016 mM 10 3 mole litre
CS_k_cit meta_CS_k_cit 0.42 mM 10 3 mole litre
CS_k_coa meta_CS_k_coa 0.07 mM 10 3 mole litre
CS_Vmax meta_CS_Vmax 4.2 mmole_per_min 10 3 mole 60 s
NDKGTPM_keq meta_NDKGTPM_keq 1.0 dimensionless None
NDKGTPM_k_atp meta_NDKGTPM_k_atp 1.33 mM 10 3 mole litre
NDKGTPM_k_adp meta_NDKGTPM_k_adp 0.042 mM 10 3 mole litre
NDKGTPM_k_gtp meta_NDKGTPM_k_gtp 0.15 mM 10 3 mole litre
NDKGTPM_k_gdp meta_NDKGTPM_k_gdp 0.031 mM 10 3 mole litre
NDKGTPM_Vmax meta_NDKGTPM_Vmax 420.0 mmole_per_min 10 3 mole 60 s
OAAFLX_Vmax meta_OAAFLX_Vmax 0.0 mmole_per_min 10 3 mole 60 s
ACOAFLX_Vmax meta_ACOAFLX_Vmax 0.0 mmole_per_min 10 3 mole 60 s
CITFLX_Vmax meta_CITFLX_Vmax 0.0 mmole_per_min 10 3 mole 60 s

Rules [52]   assignment name derived units sbo cvterm
cyto = V_cyto litre
mito = V_mito m 3
V_mito = f_mito V_cyto litre
flux_conversion = mumole_per_mmole bodyweight 1 1000 kg
f_gly = scale None
f_glyglc = scale None
ins = x_ins2 x_ins1 x_ins2 glc_ext x_ins4 glc_ext x_ins4 x_ins3 x_ins4 10 12 mole litre
ins_norm = max 0 ins x_ins2 10 12 mole litre
glu = x_glu2 x_glu1 x_glu2 1 glc_ext x_glu4 glc_ext x_glu4 x_glu3 x_glu4 10 12 mole litre
glu_norm = max 0 glu x_glu2 10 12 mole litre
epi = x_epi2 x_epi1 x_epi2 1 glc_ext x_epi4 glc_ext x_epi4 x_epi3 x_epi4 10 12 mole litre
epi_norm = max 0 epi x_epi2 10 12 mole litre
K_ins = x_ins1 x_ins2 K_val 1 -12 mole litre
K_glu = x_glu1 x_glu2 K_val 1 -12 mole litre
K_epi = x_epi1 x_epi2 K_val 1 -12 mole litre
gamma = 0.5 1 ins_norm ins_norm K_ins max glu_norm glu_norm K_glu epi_f epi_norm epi_norm K_epi None
nadh_tot meta_1d5d26c08dcd4f9faad68a73686d78c7 = nadh nad 10 3 mole litre
atp_tot meta_64d0418312a0486388d29216b7c374ef = atp adp amp 10 3 mole litre
utp_tot meta_c13bd19faebb4637974cc3b38cbc65ad = utp udp udpglc 10 3 mole litre
gtp_tot meta_d20842bbc6a248e6bef750a932609d0e = gtp gdp 10 3 mole litre
nadh_mito_tot meta_6a648c9c888a4310b3fb77e46d80edaa = nadh_mito nad_mito 10 3 mole litre
atp_mito_tot meta_54f88c313e1b472f8095c178b17fad75 = atp_mito adp_mito 10 3 mole litre
gtp_mito_tot meta_11cd9fc8ae36458d99fc7ec9fc352c8f = gtp_mito gdp_mito 10 3 mole litre
HGP = GLUT2 flux_conversion 10 3 mole 1000 kg 60 s
GNG = GPI flux_conversion 10 3 mole 1000 kg 60 s
GLY = G16PI flux_conversion 10 3 mole 1000 kg 60 s
GK_gc_free = glc GK_n_gkrp glc GK_n_gkrp GK_k_glc1 GK_n_gkrp 1 GK_b fru6p fru6p GK_k_fru6p None
GS_fs = 1 GS_k1_max GS_C glyglc GS_C glyglc GS_k1_max GS_C None
GSn_k_udpglc = GSn_k1 glc6p GSn_k2 litre 1000 mole m 6
GSp_k_udpglc = GSp_k1 glc6p GSp_k2 litre 1000 mole m 6
GSn = f_glyglc GS_Vmax GS_fs udpglc GSn_k_udpglc udpglc 0.001 mole 60 s
GSp = f_glyglc GS_Vmax GS_fs udpglc GSp_k_udpglc udpglc 0.001 mole 60 s
GP_fmax = 1 GS_k1_max glyglc glyglc GS_k1_max GS_C None
GPn_Vmax = f_glyglc GP_Vmax GP_fmax GPn_base_amp GPn_max_amp GPn_base_amp amp amp GPn_ka_amp 0.001 mole 60 s
GPn = GPn_Vmax GPn_k_glyglc GPn_k_phos glyglc phos glc1p GP_keq 1 glyglc GPn_k_glyglc 1 phos GPn_k_phos 1 glc1p GPn_k_glc1p 1 0.001 mole 60 s
GPp_Vmax = f_glyglc GP_Vmax GP_fmax 10 2 GPp_ki_glc glc 0.001 mole 60 s
GPp = GPp_Vmax GPp_k_glyglc GPp_k_phos glyglc phos glc1p GP_keq 1 glyglc GPp_k_glyglc 1 phos GPp_k_phos 1 glc1p GPp_k_glc1p 1 0.001 mole 60 s
PFK2n = f_gly PFK2_Vmax fru6p PFK2n_n fru6p PFK2n_n PFK2n_k_fru6p PFK2n_n atp atp PFK2n_k_atp 0.000999999999999996 mole 0 60 s
PFK2p = f_gly PFK2_Vmax fru6p PFK2p_n fru6p PFK2p_n PFK2p_k_fru6p PFK2p_n atp atp PFK2p_k_atp 0.001 mole 60 s
FBP2n = f_gly FBP2_Vmax 1 fru6p FBP2n_ki_fru6p fru26bp FBP2n_k_fru26bp fru26bp 0.001 mole 60 s
FBP2p = f_gly FBP2_Vmax 1 fru6p FBP2p_ki_fru6p fru26bp FBP2p_k_fru26bp fru26bp 0.001 mole 60 s
PKn_f = fru16bp PKn_n_fbp PKn_k_fbp PKn_n_fbp fru16bp PKn_n_fbp None
PKp_f = fru16bp PKp_n_fbp PKp_k_fbp PKp_n_fbp fru16bp PKp_n_fbp None
PKn_alpha_inp = 1 PKn_f PKn_alpha PK_ae PK_ae None
PKp_alpha_inp = 1 PKp_f PKp_alpha PK_ae PK_ae None
PKn_pep_inp = 1 PKn_f PKn_k_pep PKn_k_pep_end PKn_k_pep_end 0.001 mole litre
PKp_pep_inp = 1 PKp_f PKp_k_pep PKn_k_pep_end PKn_k_pep_end 0.001 mole litre
PKn = f_gly PK_Vmax PKn_alpha_inp pep PKn_n PKn_pep_inp PKn_n pep PKn_n adp adp PK_k_adp PKn_ba 1 PKn_ba PKn_f 0.001 mole 60 s
PKp = f_gly PK_Vmax PKp_alpha_inp pep PKp_n PKp_pep_inp PKp_n pep PKp_n adp adp PK_k_adp PKp_ba 1 PKp_ba PKp_f 0.001 mole 60 s
PDH_base = f_gly PDH_Vmax pyr_mito pyr_mito PDH_k_pyr nad_mito nad_mito PDH_k_nad 1 nadh_mito PDH_ki_nadh coa_mito coa_mito PDH_k_coa 1 acoa_mito PDH_ki_acoa 0.001 mole 60 s
PDHn = PDH_base PDHn_alpha 0.001 mole 60 s
PDHp = PDH_base PDHp_alpha 0.001 mole 60 s

Reactions [36] name equation modifiers kinetic law derived units sbo cvterm
GLUT2 meta_GLUT2 GLUT2 glucose transporter
glc_ext ⇆ glc f_gly GLUT2_Vmax GLUT2_k_glc glc_ext glc GLUT2_keq 1 glc_ext GLUT2_k_glc glc GLUT2_k_glc 0.001 mole 60 s
BQB_IS
SBO:0000185; P11168; PR:000015064
BQB_IS_VERSION_OF
GO:1904659
GK meta_GK Glucokinase
glc + atp ➞ glc6p + adp + h glc1p
fru6p
f_gly GK_Vmax GK_gc_free atp GK_k_atp atp glc GK_n glc GK_n GK_k_glc GK_n 0.001 mole 60 s
G6PASE meta_G6PASE D-Glucose-6-phosphate Phosphatase
glc6p + h2o ➞ glc + phos f_gly G6PASE_Vmax glc6p G6PASE_k_glc6p glc6p 0.001 mole 60 s
GPI meta_GPI D-Glucose-6-phosphate Isomerase
glc6p ⇆ fru6p f_gly GPI_Vmax GPI_k_glc6p glc6p fru6p GPI_keq 1 glc6p GPI_k_glc6p fru6p GPI_k_fru6p 0.001 mole 60 s
G16PI meta_G16PI Glucose 1-phosphate 1,6-phosphomutase
glc1p ⇆ glc6p f_glyglc G16PI_Vmax G16PI_k_glc1p glc1p glc6p G16PI_keq 1 glc1p G16PI_k_glc1p glc6p G16PI_k_glc6p 0.001 mole 60 s
UPGASE meta_UPGASE UTP:Glucose-1-phosphate uridylyltransferase
glc1p + h + utp ⇆ pp + udpglc f_glyglc UPGASE_Vmax UPGASE_k_utp UPGASE_k_glc1p utp glc1p udpglc pp UPGASE_keq 1 utp UPGASE_k_utp 1 glc1p UPGASE_k_glc1p 1 udpglc UPGASE_k_udpglc 1 pp UPGASE_k_pp 1 0.001 mole 60 s
PPASE meta_PPASE Pyrophosphate phosphohydrolase
pp + h2o ➞ h + 2.0 phos f_glyglc PPASE_Vmax pp pp PPASE_k_pp 0.001 mole 60 s
GS meta_GS Glycogen synthase
udpglc + h2o ➞ udp + h + glyglc glc6p 1 gamma GSn gamma GSp 0.001 mole 60 s
GP meta_GP Glycogen-Phosphorylase
glyglc + phos ⇆ glc1p + h2o phos
amp
glc
1 gamma GPn gamma GPp 0.001 mole 60 s
NDKGTP meta_NDKGTP Nucleoside-diphosphate kinase (ATP, GTP)
atp + gdp ⇆ adp + gtp f_gly NDKGTP_Vmax NDKGTP_k_atp NDKGTP_k_gdp atp gdp adp gtp NDKGTP_keq 1 atp NDKGTP_k_atp 1 gdp NDKGTP_k_gdp 1 adp NDKGTP_k_adp 1 gtp NDKGTP_k_gtp 1 0.001 mole 60 s
NDKUTP meta_NDKUTP Nucleoside-diphosphate kinase (ATP, UTP)
atp + udp ⇆ adp + utp f_glyglc NDKUTP_Vmax NDKUTP_k_atp NDKUTP_k_udp atp udp adp utp NDKUTP_keq 1 atp NDKUTP_k_atp 1 udp NDKUTP_k_udp 1 adp NDKUTP_k_adp 1 utp NDKUTP_k_utp 1 0.001 mole 60 s
AK meta_AK ATP:AMP phosphotransferase (Adenylatkinase)
amp + atp ⇆ 2.0 adp f_gly AK_Vmax AK_k_atp AK_k_amp atp amp adp adp AK_keq 1 atp AK_k_atp 1 amp AK_k_amp 1 adp AK_k_adp 1 adp AK_k_adp 1 0.001 mole 60 s
PFK2 meta_PFK2 ATP:D-fructose-6-phosphate 2-phosphotransferase
fru6p + atp ➞ fru26bp + adp + h 1 gamma PFK2n gamma PFK2p 0.001 mole 60 s
FBP2 meta_FBP2 D-Fructose-2,6-bisphosphate 2-phosphohydrolase
fru26bp + h2o ➞ fru6p + phos 1 gamma FBP2n gamma FBP2p 0.001 mole 60 s
PFK1 meta_PFK1 ATP:D-fructose-6-phosphate 1-phosphotransferase
fru6p + atp ➞ fru16bp + adp + h fru26bp f_gly PFK1_Vmax 1 1 1 fru26bp PFK1_ka_fru26bp fru6p atp PFK1_ki_fru6p PFK1_k_atp PFK1_k_fru6p atp PFK1_k_atp fru6p atp fru6p 0.001 mole 60 s
FBP1 meta_FBP1 D-Fructose-1,6-bisphosphate 1-phosphohydrolase
fru16bp + h2o ➞ fru6p + phos fru26bp f_gly FBP1_Vmax 1 fru26bp FBP1_ki_fru26bp fru16bp fru16bp FBP1_k_fru16bp 0.001 mole 60 s
ALD meta_ALD Aldolase
fru16bp ⇆ grap + dhap f_gly ALD_Vmax ALD_k_fru16bp fru16bp grap dhap ALD_keq 1 fru16bp ALD_k_fru16bp grap ALD_ki1_grap dhap grap ALD_k_grap ALD_k_dhap ALD_ki1_grap fru16bp grap ALD_k_fru16bp ALD_ki2_grap 0.001 mole 60 s
TPI meta_TPI Triosephosphate Isomerase
dhap ⇆ grap f_gly TPI_Vmax TPI_k_dhap dhap grap TPI_keq 1 dhap TPI_k_dhap grap TPI_k_grap 0.001 mole 60 s
GAPDH meta_GAPDH D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase
grap + nad + phos ⇆ bpg13 + nadh + h f_gly GAPDH_Vmax GAPDH_k_nad GAPDH_k_grap GAPDH_k_phos nad grap phos bpg13 nadh GAPDH_keq 1 nad GAPDH_k_nad 1 grap GAPDH_k_grap 1 phos GAPDH_k_phos 1 nadh GAPDH_k_nadh 1 bpg13 GAPDH_k_bpg13 1 0.001 mole 60 s
PGK meta_PGK Phosphoglycerate Kinase
adp + bpg13 ⇆ atp + pg3 f_gly PGK_Vmax PGK_k_adp PGK_k_bpg13 adp bpg13 atp pg3 PGK_keq 1 adp PGK_k_adp 1 bpg13 PGK_k_bpg13 1 atp PGK_k_atp 1 pg3 PGK_k_pg3 1 0.001 mole 60 s
PGM meta_PGM 2-Phospho-D-glycerate 2,3-phosphomutase
pg3 ⇆ pg2 f_gly PGM_Vmax pg3 pg2 PGM_keq pg3 PGM_k_pg3 1 pg2 PGM_k_pg2 0.001 mole 60 s
BQB_IS
SBO:0000176; 5.4.2.1; R01518; GO:0004619
BQB_IS_VERSION_OF
15904
BQB_HAS_VERSION
P18669; P15259; PR:000012592; PR:000012593
EN meta_EN 2-Phospho-D-glycerate hydro-lyase (enolase)
pg2 ⇆ h2o + pep f_gly EN_Vmax pg2 pep EN_keq pg2 EN_k_pg2 1 pep EN_k_pep 0.001 mole 60 s
PK meta_PK Pyruvatkinase
pep + adp + h ➞ pyr + atp fru16bp 1 gamma PKn gamma PKp 0.001 mole 60 s
PEPCK meta_PEPCK PEPCK cyto
gtp + oaa ⇆ co2 + gdp + pep f_gly PEPCK_Vmax PEPCK_k_oaa PEPCK_k_gtp oaa gtp pep gdp co2 PEPCK_keq 1 oaa PEPCK_k_oaa 1 gtp PEPCK_k_gtp 1 pep PEPCK_k_pep 1 gdp PEPCK_k_gdp 1 co2 PEPCK_k_co2 1 0.001 mole 60 s
PEPCKM meta_PEPCKM PEPCK mito
gtp_mito + oaa_mito ⇆ co2_mito + gdp_mito + pep_mito f_gly PEPCKM_Vmax PEPCK_k_oaa PEPCK_k_gtp oaa_mito gtp_mito pep_mito gdp_mito co2_mito PEPCK_keq 1 oaa_mito PEPCK_k_oaa 1 gtp_mito PEPCK_k_gtp 1 pep_mito PEPCK_k_pep 1 gdp_mito PEPCK_k_gdp 1 co2_mito PEPCK_k_co2 1 0.001 mole 60 s
PC meta_PC Pyruvate Carboxylase
atp_mito + pyr_mito + co2_mito + h2o_mito ➞ adp_mito + oaa_mito + phos_mito + 2.0 h acoa_mito f_gly PC_Vmax atp_mito PC_k_atp atp_mito pyr_mito PC_k_pyr pyr_mito co2_mito PC_k_co2 co2_mito acoa_mito PC_n acoa_mito PC_n PC_k_acoa PC_n 0.001 mole 60 s
LDH meta_LDH Lactate Dehydrogenase
pyr + nadh + h ⇆ lac + nad f_gly LDH_Vmax LDH_k_pyr LDH_k_nadh pyr nadh lac nad LDH_keq 1 nadh LDH_k_nadh 1 pyr LDH_k_pyr 1 lac LDH_k_lac 1 nad LDH_k_nad 1 0.001 mole 60 s
LACT meta_LACT Lactate transport (import)
lac_ext ⇆ lac f_gly LACT_Vmax LACT_k_lac lac_ext lac LACT_keq 1 lac_ext LACT_k_lac lac LACT_k_lac 0.001 mole 60 s
BQB_IS
SBO:0000185; GO:0035879
BQB_IS_VERSION_OF
PR:000015168
BQB_HAS_VERSION
Q1EHB4; Q8N695
PYRTM meta_PYRTM Pyruvate transport (mito)
pyr ⇆ pyr_mito f_gly PYRTM_Vmax PYRTM_k_pyr pyr pyr_mito PYRTM_keq 1 pyr PYRTM_k_pyr pyr_mito PYRTM_k_pyr 0.001 mole 60 s
PEPTM meta_PEPTM PEP Transport (export mito)
pep_mito ⇆ pep f_gly PEPTM_Vmax PEPTM_k_pep pep_mito pep PEPTM_keq 1 pep PEPTM_k_pep pep_mito PEPTM_k_pep 0.001 mole 60 s
PDH meta_PDH Pyruvate Dehydrogenase
pyr_mito + coa_mito + nad_mito ➞ acoa_mito + co2_mito + nadh_mito 1 gamma PDHn gamma PDHp 0.001 mole 60 s
CS meta_CS Citrate Synthase
acoa_mito + oaa_mito + h2o_mito ⇆ cit_mito + coa_mito + h_mito f_gly CS_Vmax CS_k_oaa CS_k_acoa acoa_mito oaa_mito cit_mito coa_mito CS_keq 1 acoa_mito CS_k_acoa 1 oaa_mito CS_k_oaa 1 cit_mito CS_k_cit 1 coa_mito CS_k_coa 1 0.001 mole 60 s
NDKGTPM meta_NDKGTPM Nucleoside-diphosphate kinase (ATP, GTP) mito
atp_mito + gdp_mito ⇆ adp_mito + gtp_mito f_gly NDKGTPM_Vmax NDKGTPM_k_atp NDKGTPM_k_gdp atp_mito gdp_mito adp_mito gtp_mito NDKGTPM_keq 1 atp_mito NDKGTPM_k_atp 1 gdp_mito NDKGTPM_k_gdp 1 adp_mito NDKGTPM_k_adp 1 gtp_mito NDKGTPM_k_gtp 1 0.001 mole 60 s
OAAFLX oxalacetate influx
➞ oaa_mito f_gly OAAFLX_Vmax 0.001 mole 60 s
ACOAFLX acetyl-coa efflux
acoa_mito ➞ f_gly ACOAFLX_Vmax 0.001 mole 60 s
CITFLX citrate efflux
cit_mito ➞ f_gly CITFLX_Vmax 0.001 mole 60 s