Reaction |
GLUT2 meta_GLUT2
|
GLUT2 glucose transporter
|
⇆ |
glc_ext ⇆ glc |
|
|
|
|
|
Reaction |
GK meta_GK
|
Glucokinase
|
➞ |
glc + atp ➞ glc6p + adp + h |
glc1p fru6p |
|
|
|
|
Reaction |
G6PASE meta_G6PASE
|
D-Glucose-6-phosphate Phosphatase
|
➞ |
glc6p + h2o ➞ glc + phos |
|
|
|
|
|
Reaction |
GPI meta_GPI
|
D-Glucose-6-phosphate Isomerase
|
⇆ |
glc6p ⇆ fru6p |
|
|
|
|
|
Reaction |
G16PI meta_G16PI
|
Glucose 1-phosphate 1,6-phosphomutase
|
⇆ |
glc1p ⇆ glc6p |
|
|
|
|
|
Reaction |
UPGASE meta_UPGASE
|
UTP:Glucose-1-phosphate uridylyltransferase
|
⇆ |
glc1p + h + utp ⇆ pp + udpglc |
|
|
|
|
|
Reaction |
PPASE meta_PPASE
|
Pyrophosphate phosphohydrolase
|
➞ |
pp + h2o ➞ h + 2.0 phos |
|
|
|
|
|
Reaction |
GS meta_GS
|
Glycogen synthase
|
➞ |
udpglc + h2o ➞ udp + h + glyglc |
glc6p |
|
|
|
|
Reaction |
GP meta_GP
|
Glycogen-Phosphorylase
|
⇆ |
glyglc + phos ⇆ glc1p + h2o |
phos amp glc |
|
|
|
|
Reaction |
NDKGTP meta_NDKGTP
|
Nucleoside-diphosphate kinase (ATP, GTP)
|
⇆ |
atp + gdp ⇆ adp + gtp |
|
|
|
|
|
Reaction |
NDKUTP meta_NDKUTP
|
Nucleoside-diphosphate kinase (ATP, UTP)
|
⇆ |
atp + udp ⇆ adp + utp |
|
|
|
|
|
Reaction |
AK meta_AK
|
ATP:AMP phosphotransferase (Adenylatkinase)
|
⇆ |
amp + atp ⇆ 2.0 adp |
|
|
|
|
|
Reaction |
PFK2 meta_PFK2
|
ATP:D-fructose-6-phosphate 2-phosphotransferase
|
➞ |
fru6p + atp ➞ fru26bp + adp + h |
|
|
|
|
|
Reaction |
FBP2 meta_FBP2
|
D-Fructose-2,6-bisphosphate 2-phosphohydrolase
|
➞ |
fru26bp + h2o ➞ fru6p + phos |
|
|
|
|
|
Reaction |
PFK1 meta_PFK1
|
ATP:D-fructose-6-phosphate 1-phosphotransferase
|
➞ |
fru6p + atp ➞ fru16bp + adp + h |
fru26bp |
|
|
|
|
Reaction |
FBP1 meta_FBP1
|
D-Fructose-1,6-bisphosphate 1-phosphohydrolase
|
➞ |
fru16bp + h2o ➞ fru6p + phos |
fru26bp |
|
|
|
|
Reaction |
ALD meta_ALD
|
Aldolase
|
⇆ |
fru16bp ⇆ grap + dhap |
|
|
|
|
|
Reaction |
TPI meta_TPI
|
Triosephosphate Isomerase
|
⇆ |
dhap ⇆ grap |
|
|
|
|
|
Reaction |
GAPDH meta_GAPDH
|
D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase
|
⇆ |
grap + nad + phos ⇆ bpg13 + nadh + h |
|
|
|
|
|
Reaction |
PGK meta_PGK
|
Phosphoglycerate Kinase
|
⇆ |
adp + bpg13 ⇆ atp + pg3 |
|
|
|
|
|
Reaction |
PGM meta_PGM
|
2-Phospho-D-glycerate 2,3-phosphomutase
|
⇆ |
pg3 ⇆ pg2 |
|
|
|
|
|
Reaction |
EN meta_EN
|
2-Phospho-D-glycerate hydro-lyase (enolase)
|
⇆ |
pg2 ⇆ h2o + pep |
|
|
|
|
|
Reaction |
PK meta_PK
|
Pyruvatkinase
|
➞ |
pep + adp + h ➞ pyr + atp |
fru16bp |
|
|
|
|
Reaction |
PEPCK meta_PEPCK
|
PEPCK cyto
|
⇆ |
gtp + oaa ⇆ co2 + gdp + pep |
|
|
|
|
|
Reaction |
PEPCKM meta_PEPCKM
|
PEPCK mito
|
⇆ |
gtp_mito + oaa_mito ⇆ co2_mito + gdp_mito + pep_mito |
|
|
|
|
|
Reaction |
PC meta_PC
|
Pyruvate Carboxylase
|
➞ |
atp_mito + pyr_mito + co2_mito + h2o_mito ➞ adp_mito + oaa_mito + phos_mito + 2.0 h |
acoa_mito |
|
|
|
|
Reaction |
LDH meta_LDH
|
Lactate Dehydrogenase
|
⇆ |
pyr + nadh + h ⇆ lac + nad |
|
|
|
|
|
Reaction |
LACT meta_LACT
|
Lactate transport (import)
|
⇆ |
lac_ext ⇆ lac |
|
|
|
|
|
Reaction |
PYRTM meta_PYRTM
|
Pyruvate transport (mito)
|
⇆ |
pyr ⇆ pyr_mito |
|
|
|
|
|
Reaction |
PEPTM meta_PEPTM
|
PEP Transport (export mito)
|
⇆ |
pep_mito ⇆ pep |
|
|
|
|
|
Reaction |
PDH meta_PDH
|
Pyruvate Dehydrogenase
|
➞ |
pyr_mito + coa_mito + nad_mito ➞ acoa_mito + co2_mito + nadh_mito |
|
|
|
|
|
Reaction |
CS meta_CS
|
Citrate Synthase
|
⇆ |
acoa_mito + oaa_mito + h2o_mito ⇆ cit_mito + coa_mito + h_mito |
|
|
|
|
|
Reaction |
NDKGTPM meta_NDKGTPM
|
Nucleoside-diphosphate kinase (ATP, GTP) mito
|
⇆ |
atp_mito + gdp_mito ⇆ adp_mito + gtp_mito |
|
|
|
|
|
Reaction |
OAAFLX
|
oxalacetate influx
|
➞ |
➞ oaa_mito |
|
|
|
|
|
Reaction |
ACOAFLX
|
acetyl-coa efflux
|
➞ |
acoa_mito ➞ |
|
|
|
|
|
Reaction |
CITFLX
|
citrate efflux
|
➞ |
cit_mito ➞ |
|
|
|
|
|