Matthias König is a computational systems biologist specializing in digital twins, physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling, and precision medicine. He leads research at the interface of mechanistic modeling, data science, and clinical translation, with a focus on liver and kidney function. He develops interoperable, reproducible digital twin frameworks for personalized healthcare. His work integrates multi-scale modeling, real-world clinical data, and open-science standards to enable predictive and patient-specific decision support in transplantation and metabolic disease.