impairment¶

The classes of impaired organ function: the factors of their parameters and colors.

The models scale a parameter of an organ by these factors, the renal function by KI__f_renal_function, the cirrhosis by f_cirrhosis (the degree of the liver which is cirrhotic) and the cardiac function by the cardiac output; the colors draw a class in every figure of the model alike. The base of the experiments of a model (pkpdsim.experiment.PKPDSimulationExperiment) has RENAL_FUNCTION, CIRRHOSIS and CARDIAC as its maps; a model which defines the classes otherwise assigns another preset in its base.

The models built on the PBPK library (pkpdsim.pbpk.impairment) have other parameters: CP_severity (liver cirrhosis, 0 healthy and 1, 2, 3 the Child-Pugh classes A, B, C), f_renal_function (the GFR relative to healthy, which gives the stage of chronic kidney disease) and HF_severity (heart failure, 0 healthy and 1 to 4 the NYHA classes I to IV). Their maps are CHILD_PUGH (colors CIRRHOSIS_COLORS), the RENAL_FUNCTION presets and HEART_FAILURE (colors HEART_FAILURE_COLORS); the maps of the other models keep their values and meaning.