Lecture: Structural Models

This lecture explores structural pharmacokinetic models, focusing on the relationships between dose, clearance, and volume of distribution, and how physicochemical properties and parameter variability influence drug exposure.

Learning Objectives

The main learning objectives are

• 🎯 Explain the relationship between Dose, Volume of Distribution (V), and Clearance (CL) using a simple algebraic model.
• 🎯 Recognize variability in pharmacokinetic parameters (such as CL and V) between different drugs and how this impacts drug exposure.
• 🎯 Develop a basic understanding of physicochemical properties (e.g., lipophilicity, molecular weight, solubility) and how they relate to pharmacokinetic behavior.
• 🎯 Understand the concept and utility of a parameter scan in pharmacokinetic modeling.
• 🎯 Explore the effects of changing V, Dose, or CL on drug concentration.

Lecture

Download: L02_Koenig_MB19_Structural.Models.pdf