Lecture: Ordinary Differential Equations (ODE) & Compartment Models

This lecture introduces the use of ordinary differential equations (ODEs) in pharmacokinetic modeling, focusing on compartment models, numerical integration, and the simulation of drug concentration-time profiles.

Learning Objectives

The main learning objectives are

  • 🎯 Understand the role of ODEs in pharmacokinetic modeling to describe dynamic changes in drug concentration over time.
  • 🎯 Interpret ODEs used in simple compartment models.
  • 🎯 Gain basic intuition for numerical integration methods, such as Euler’s method methods.
  • 🎯 Apply numerical integration techniques to simulate drug concentration-time profiles.
  • 🎯 Understand how ODE-based models are implemented in simulation tools and programming environments (e.g., Python).

Lecture

Download: L03_Koenig_MB19_ODE.Compartment.Models.pdf