Lecture: Metabolism

This lecture provides an overview of drug metabolism, covering phase I and II processes, enzyme variability, metabolic kinetics, prodrug activation, and the impact of enzyme interactions on drug clearance and drug-drug interactions.

Learning Objectives

The main learning objectives are

• 🎯 Provide an overview of metabolic pathways relevant to drug metabolism.
• 🎯 Understand phase I and phase II metabolism and their role in drug transformation.
• 🎯 Explain the concept of prodrugs and their activation via metabolism.
• 🎯 Recognize the variability in enzyme expression and the impact of isoforms (e.g., CYPs) on drug metabolism.
• 🎯 Describe metabolic reaction kinetics using mass action, Michaelis-Menten, and Hill equations.
• 🎯 Understand enzyme inhibition and activation, and how they affect drug clearance.
• 🎯 Explore drug-drug interactions mediated by metabolic pathways.

Lecture

Download: L05_Koenig_MB19_Metabolization.pdf