Lecture: Interindividual Variability

This lecture examines interindividual variability in pharmacokinetics, exploring how genetic, physiological, and lifestyle factors influence ADME processes and highlighting the importance of variability for dose optimization and personalized medicine.

Learning Objectives

The main learning objectives are

• 🎯 Understand the concept of interindividual variability and its relevance in pharmacokinetics.
• 🎯 Identify key factors influencing variability in drug absorption, distribution, metabolism, and excretion (ADME).
• 🎯 Explain the role of genetics, age, sex, body weight, and organ function in pharmacokinetic variability.
• 🎯 Recognize the impact of drug-drug interactions and lifestyle factors (e.g. diet, smoking, alcohol) on pharmacokinetics.
• 🎯 Interpret pharmacokinetic data from subpopulations (e.g., pediatric, elderly, renally impaired).
• 🎯 Appreciate the importance of accounting for variability in dose optimization and personalized medicine.

Lecture

Download: L07_Koenig_MB19_Variability.pdf